Erratum to: PLCζ disruption with complete fertilization failure in normozoospermia
نویسندگان
چکیده
منابع مشابه
I-13: Complete Fertilization Failure after ICSIWhat to Do?
Fertilization in vivo is a complex process consisting of six steps, namely, penetration of the cumulus complex, binding of the sperm to the zona pellucida, fusion of oocyte and sperm, oocyte activation, sperm remodelling, and formation of the pronuclei. Since ICSI bypasses the first three steps any problem related to fertilization failure after ICSI arises from oocyte activation onwards. Accord...
متن کاملHuman PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation.
A sperm-specific phospholipase C-zeta (PLCζ) is believed to play an essential role in oocyte activation during mammalian fertilization. Sperm PLCζ has been shown to trigger a prolonged series of repetitive Ca(2+) transients or oscillations in oocytes that precede activation. This remarkable intracellular Ca(2+) signalling phenomenon is a distinctive characteristic observed during in vitro ferti...
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With the introduction of intracytoplasmic sperm injection (ICSI), couples with severe male factor infertility have achieved fertilization and clinical pregnancy rates comparable to other in-vitro fertilization (IVF) patients. However, failure of fertilization still occurs in some patients despite the utilization of microsurgical sperm injection techniques. How such fertilization failure after I...
متن کاملART failure: oocyte contributions to unsuccessful fertilization.
BACKGROUND The complexity of fertilization failure during assisted reproductive technologies (ART) is often under-appreciated, as this failure can occur at any number of essential mechanistic and cellular events. Importantly, successful fertilization is heavily dependent upon inherent qualities of the oocytes, and thus reliant upon fidelity of oocyte maturation. METHODS Pubmed and medline wer...
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a:4:{s:10:"Background";s:363:"The largest percentage of failed in vitro fertilization (IVF) cycles are due to lack of implantation. As hereditary thrombophilia can cause in placentation failure, it may have a role in recurrent IVF failure. The aim of this case-control study was to determine whether or not hereditary thrombophilia is more prevalent in women with recurrent IVF failures.";s:19:"Ma...
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ژورنال
عنوان ژورنال: Journal of Assisted Reproduction and Genetics
سال: 2015
ISSN: 1058-0468,1573-7330
DOI: 10.1007/s10815-015-0522-2